“perhaps the greatest intellectual stride that it has ever been granted to any man to make”— Einstein on Newton’s PrincipiaNEWTON ,ISAAC
Philosophiae Naturalis Principia Mathematica. London: for the Royal Society by Joseph Streater, 1687
First edition of Isaac Newton’s Principia, “generally described as the greatest work in the history of science” (PMM). This is an excellent, entirely unrestored copy of the first state with the preferred two-line imprint.
WATSON, JAMES D. & FRANCIS CRICK
“Molecular structure of nucleic acids. A structure of deoxyribose nucleic acid.” Offprint from: Nature Vol. 171 (April 25, 1953). London, 1953
FIRST EDITION, THE RARE OFFPRINT. Signed by Watson and Crick. This volume is also inscribed and signed by Maurice Wilkins and Alec R. Stokes, co-authors of the second paper with H R. Wilson. Wilkins shared the 1962 Nobel Prize in Medicine with Watson and Crick.
VON NEUMANN ,JOHN, ET AL
Ergebnisse eines mathematischen Kolloquiums, unter Mitwirkung Kurt Gödel und George Nobeling. Herausgegen von Kurt Menger. Heft 1-8.. Leipzig & Berlin: B. G. Teubner and F. Deuticke, [1931-1937].
A rare complete run of first editions of the proceedings of the celebrated Vienna Colloquium.
Iconic signed Darwin photograph “I like this photograph much better than any other which has been taken of me.”(DARWIN, CHARLES.) CAMERON, JULIA MARGARET
Portrait of Charles Darwin, signed by Darwin and by Cameron. Cameron, 
THE ICONIC PORTRAIT OF CHARLES DARWIN, boldly signed by Charles Darwin and by Julia Margaret Cameron.
WATSON, JAMES D. & Andrew Berry
DNA The Secret of Life. [New York: Knopf, 2003.]
Presentation copy inscribed by James Watson to Francis Crick and his wife: “For Francis and Odile from Jim 27 November 2002.” This is the dedication copy, with the printed dedication stating “To Francis Crick.”
Experiments and Observations in Soaring Flight. Offprint from: Journal of the Western Society of Engineers 8 [misprinted “III” on front wrapper], no. 4 (August, 1903). [Chicago], 
FIRST EDITION, offprint issue. Presentation copy with the stamp of the Wrights’ advisor, mentor, and chief promoter, aviation pioneer Octave Chanute. Chanute was the most important figure in aviation from 1890 to 1910
Autograph Letter Signed [to Henry Denny]. Down, Kent, June 1, 
VERY EARLY DARWIN INVESTIGATION OF THE RACES OF MAN. In 1834 Darwin heard that head lice vary among the races of man while on the voyage of the Beagle. In his Beagle zoological diary he wrote, “Mr Martial, a surgeon of an English Whaler assures me that the Lice of the Sandwich Islanders … if they strayed to the bodies of the English in 3 or 4 days died … If these facts were verified their interest would be great.— Man springing from one stock according his varieties having different species of parasites.— It leads one into many reflections.” Intrigued by the implications of this observation, Darwin began collecting specimens for further research.
Neil Armstrong on the Cancellation of the Moon Stamp On Board the Apollo XI CSM Returning From the MoonARMSTRONG ,NEIL
Typed letter signed to Dr. Joseph F. Rorke.. Houston, NASA, 15 January 1970.
In this historic letter Armstrong details the history of the Apollo XI in-flight cancellation of the “First Man on the Moon” stamp and of the die famously carried to the moon by Armstrong, Aldrin, and Collins
Scientific manuscript of a course of studies at Collège de la Trinité, Lyon. Lyon, 1660s
This fascinating 17th-century scientific manuscript documents the state of scientific knowledge and education in France in the years following Galileo’s trial and the Church’s prohibition of Copernican theory.
“I believe the high value of well-bred males is due to their transmitting their good qualities to a far greater number of offspring than can the female.”DARWIN, CHARLES
Autograph Letter Signed to Lawson Tait. Down, 17 January 
CHARLES DARWIN ON SEXUALITY AND THE TRANSMISSION OF HEREDITARY CHARACTERISTICS.