Experiments and Observations on Electricity, Made at Philadelphia in America.. London: Printed for David Henry, and sold by Francis Newbery, 1769
A very rare inscribed presentation copy of “the most important scientific book of eighteenth-century America” (PMM), inscribed by Benjamin Franklin: “To Mr. Livesy from his obliged Friend & humble Servant The Author.”
Die Grundlage der allgemeinen Relativitaetstheorie. Leipzig: Barth, 1916
First separate edition, first printing (i.e. with the Metzger & Wittig imprints). A spectacular inscribed copy signed by Einstein and further inscribed by Einstein with a long note concerning gravitation, electromagnetic theory, and quantum theory.
(APOLLO 11) Neil Armstrong, Buzz Aldrin,and Michael Collins
United States flag flown to the Moon on Apollo 11. NASA, July 16-24, 1969
This American flag, flown to the Moon on Apollo 11, is one of the most sought-after relics of space exploration.
the only known copy of a landmark work of Copernicanism, printed by the printer of De Revolutionibus(COPERNICUS.) GASSER, ACHILLES PIRMIN
Practica auff das M.D.XLvj. jar, durch Doctorem Achillem P. Gasser L. zu Feldkirch gemacht. Nuremberg, J. Petreius, 1545
First edition of the only known copy of a landmark work of Copernicanism. Gasser’s Practica contains the first account of Copernican heliocentrism printed in a vernacular language. It is “as concise and accessible a summary of heliocentrism as one could wish for” (Danielson). This “enthusiastic hymn of praise to Copernicus” (Burmeister) was printed by the printer of De Revolutionibus.
WATSON, JAMES D. & FRANCIS CRICK
“Molecular structure of nucleic acids. A structure of deoxyribose nucleic acid.” Offprint from: Nature Vol. 171 (April 25, 1953). London, 1953
FIRST EDITION, THE RARE OFFPRINT signed by James Watson, Francis Crick, Maurice Wilkins, and Raymond Gosling.
Apollo Lunar Module lithograph signed by all twelve men who have walked on the Moon, dozens of other astronauts, and scores of NASA and Grumman officials and other figures associated with the Apollo program.. [NASA and Grumman], ca. 1972.
The spectacular color lithograph of the Apollo Lunar Module is surrounded by more than 300 signatures including the twelve men who have walked on the Moon, 25 additional Apollo astronauts, various political and aerospace leaders, and numerous Grumman and NASA engineers, officers, and other personnel.
(DARWIN, CHARLES.) CAMERON, JULIA MARGARET
Profile bust portrait of Charles Darwin, signed by Cameron. London: Colnaghi, 1868
The great Darwin portrait, Julia Margaret Cameron’s 1868 profile of Darwin is probably the most famous photograph of a 19th-century scientist. Darwin remarked, “I like this photograph very much better than any other which has been taken of me.”
MUNSON, LAURA GORDON
Flowers from My Garden. Sketched and Painted from Nature. [New York], 
FIRST EDITION, a unique pre-publication copy with 18 fine watercolors, the original art used as the basis for the lithographs in the published edition.
(APOLLO 11.) ARMSTRONG, NEIL and BUZZ ALDRIN
Armstrong and Aldrin raising the U.S. flag on the Moon’s surface. NASA, 
Signed by Neil Armstrong and Buzz Aldrin, the first two men on the Moon. This image was taken by the Maurer Data Acquisition Camera (DAC, pronounced “dak”). The DAC made films through the Lunar Module Pilot’s window during the approach and landing of the LM and took stop motion photographs during the EVA at the rate of one frame per second.
Autograph manuscript observations of her discovery of a comet. [Slough], 22 December 88
In this wonderful scientific manuscript Caroline Herschel records her observations of her newly-discovered comet, known today as 35P/Herschel-Rigollet.